氢氧化钠厂家介绍说，传统意义上的C-H键活化中，贵金属催化占据了主导地位。贵金属的使用增加了成本，限制了C-H键活化的实际应用。因此，人们一直尝试寻找从大量存在、便宜易得的主族金属出发实现C-H键的活化。2015年，BrianStoltz教授和RobertGrubbs教授课题组在Nature上报道了使用KOtBu催化芳香杂环的sp2C-H键的硅基化反应,引起了化学家的普遍关注。鉴于炔基硅类化合物在有机合成的重要应用，团队考虑将该体系拓展到炔基硅类化合物的制备中。
Sodium hydroxide manufacturers said that noble metal catalysis plays a leading role in the traditional C-H bond activation. The use of precious metals increases the cost and limits the practical application of C-H bond activation. Therefore, people have been trying to find a large number of cheap and easily available main group metals to realize the activation of C-H bond. In 2015, professor Brian Stoltz and Professor Robert Grubbs reported on nature that kotbu was used to catalyze the silylation of sp2C-H bond of aromatic heterocycles, which attracted the general attention of chemists. In view of the important application of alkynyl silicon compounds in organic synthesis, the team considered extending the system to the preparation of alkynyl silicon compounds.

氢氧化钠厂家常用的传统制备炔基硅类化合物是从末端炔出发，主要有以下两种路线（Scheme1a）：碱拔去质子、进攻亲电的Si-X物种，从而得到炔基硅（路线A）；过渡金属催化的炔烃直接硅基化反应（路线B）。近些年试验发现，MgO、LiAH4甚至醇盐在末端炔与硅氢物种的脱氢偶联中也展现了催化活性。然而，这些研究底物局限性大，产率、选择性均中等，反应温度也较高，因而降低了适用性。
The traditional preparation of alkynyl silicon compounds commonly used by sodium hydroxide manufacturers starts from terminal alkynes, which mainly includes the following two routes (scheme 1a): alkali pulls out protons and attacks electrophilic si-x species to obtain alkynyl silicon (route a); Transition metal catalyzed direct silylation of alkynes (route b). In recent years, it has been found that MgO, liah4 and even alkoxides also show catalytic activity in the dehydrogenation coupling of terminal alkynes with silyl hydrogen species. However, the limitations of these substrates are large, the yield and selectivity are medium, and the reaction temperature is also high, which reduces the applicability.
重要的是，尽管有使用价格很贵的CF3TMS实现含杂环的炔烃硅基化的报道，大多数含杂环或脂肪胺的末端炔均不能参与反应。在此，氢氧化钠厂家实现了简洁、效率、普适的末端炔与硅氢脱氢偶联的方法学。令人惊奇的是，氢氧化钠厂家使用的催化剂是普遍存在的NaOH或KOH。
Importantly, although there are reports of silylation of heterocyclic alkynes using expensive cf3tms, most heterocyclic or aliphatic amine containing terminal alkynes cannot participate in the reaction. Here, sodium hydroxide manufacturers have realized a simple, efficient and universal methodology for dehydrogenation coupling of terminal alkynes and silicon hydrogen. Surprisingly, the catalyst used by sodium hydroxide manufacturers is the ubiquitous NaOH or KOH.